Technion Computer Science Colloquium Time+Place : Tuesday 10/01/2012 14:30 room 337-8 Taub Bld. Speaker : Or Zuk Affiliation: Broad Institute of MIT and Harvard Host : Dan Geiger Title : Missing Heritability: New algorithmic and statistical approaches Abstract : The completion of the human genome project set a stepping stone in building catalogs of common human genetic variation. These catalogs, in turn, enabled the search for associations between common variants and complex human traits and diseases, by performing Genome-Wide Association Studies (GWAS). GWAS have been successful in discovering thousands of statistically significant, reproducible, genotype-phenotype associations. However, the discovered variants (genotypes) explain only a small fraction of the phenotypic variance in the population for most human traits. In contrast, the heritability, defined as the proportion of phenotypic variance explained by all genetic factors, was estimated to be much larger for those same traits using indirect population-based estimators. This gap is referred to as 'missing heritability'. Mathematically, heritability is defined by considering a function $F$ mapping a set of (Boolean) variables, $(x_1,.., x_n)$ representing genotypes, and additional environmental or 'noise' variables $\epsilon$, to a single (real or discrete) variable $z$, representing phenotype. We use the variance decomposition of $F$, separating the linear term, corresponding to additive (narrow-sense) heritability, and higher-order terms, representing genetic-interactions (epistasis), to explore several explanations for the 'missing heritability' mystery. We show that genetic interactions can significantly bias upwards current population-based heritability estimators, creating a false impression of 'missing heritability'. We offer a solution to this problem by providing a novel consistent estimator based on unrelated individuals. We also use the Wright-Fisher process from population genetic theory to develop and apply a novel power correction method for inferring the relative contributions of rare and common variants to heritability. Finally, we propose a novel algorithm for estimating the different variance components (beyond additive) of heritability from GWAS data. I will give the needed genetics background, and discuss the statistical methods and algorithms used. Short Bio: I am currently a post-doc at the Broad Institute of MIT and Harvard, in Eric Lander's lab. I work on computational and statistical problems arising from genomics applications, in particular in human genetics and comparative genomics. I have completed my Ph.D. in Computer Science and Applied Mathematics at the Weizmann Institute of Science under the supervision of Eytan Domany. Refreshments served from 14:15 on, Lecture starts at 14:30 ---------------------------------------------------------- Visit our home page- <http://www.cs.technion.ac.il/~colloq> --------------------------------------------------------- Technion Math. Net (TECHMATH) Editor: Michael Cwikel <techm@math.technion.ac.il> Announcement from: Hadas Heier <heier@cs.technion.ac.il>