Technion, IEM faculty - Statistics Seminar
Speaker: David Azriel, Technion
Title: Optimal sequential designs in dose-finding studies
Date: 11/12/2011
Time: 14:30
Place: Bloomfield-527
Abstract:  <>

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Phase I clinical trials are conducted in order to find the maximum
tolerated dose (MTD) of a given drug from a finite set of doses. Numerous
methods have been proposed for finding the MTD, most of them can be seen
as myopic strategies with respect to a certain loss function. Such myopic
designs are computationally feasible, but are not globally optimal.  In
this talk, I present a dynamic programming (DP) algorithm that computes
optimal designs with respect to different loss functions. DP algorithms
require heavy computations, and I will discuss several aspects of the
design that makes the calculation feasible. The new design is compared to
several existing methods.
Technion Math. Net (TECHMATH)
Editor: Michael Cwikel   <> 
Announcement from:  <>