Technion, IEM faculty - Statistics Seminar
 
Speaker: David Azriel, Technion
 
Title: Optimal sequential designs in dose-finding studies
 
Date: 11/12/2011
 
Time: 14:30
 
Place: Bloomfield-527
 
Abstract:  <http://ie.technion.ac.il/seminar_files/1315907168_Azriel.pdf>

Or read it here:

Phase I clinical trials are conducted in order to find the maximum
tolerated dose (MTD) of a given drug from a finite set of doses. Numerous
methods have been proposed for finding the MTD, most of them can be seen
as myopic strategies with respect to a certain loss function. Such myopic
designs are computationally feasible, but are not globally optimal.  In
this talk, I present a dynamic programming (DP) algorithm that computes
optimal designs with respect to different loss functions. DP algorithms
require heavy computations, and I will discuss several aspects of the
design that makes the calculation feasible. The new design is compared to
several existing methods.
 
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Technion Math. Net (TECHMATH)
Editor: Michael Cwikel   <techm@math.technion.ac.il> 
Announcement from:  <ynardi@ie.technion.ac.il>